O le Paclitaxel o se oloa fa'anatura na maua mai i le pa'u o le la'au o le Pacific yew (Taxus pacifica). lu'itau i le gaosiga moni o alamanuia. O se vaaiga lautele lenei o le paclitaxel biosynthesis:
1. Mea amata: O le biosynthesis o le paclitaxel e amata i se mea masani amata, e masani lava mai lau poʻo le paʻu o le yew tree.These mea amata o loʻo i ai matua faʻapipiʻi e mafai ona faʻaogaina e faʻapipiʻi muamua a paclitaxel.
2.Multi-enzyme catalysis: Biosynthesis opaclitaxele mana'omia ni enzymes se tele e fa'atupuina ai le tali.
3. Synthesis of intermediates: Intermediates o se laasaga autu i le tuʻufaʻatasia o le paclitaxel. Latou te aofia ai polycyclic compounds ma itu faʻapipiʻi faʻasologa faʻasolosolo e faʻasolosolo malie e ala i se faasologa o enzyme-catalyzed reactions.
4.Final synthesis o paclitaxel: O molelaula muamua mo le tuufaatasia o le paclitaxel ua faasolosolo malie lava synthesized i molelaʻau paclitaxel i le tele o tali laasaga. O tali e aofia ai polycyclic synthesis, acylation, deketone, ma isi laasaga taua.
5. Extraction ma le faʻamamaina: A maeʻa le tuʻufaʻatasia o le paclitaxel, e manaʻomia se laʻasaga faʻapipiʻi ma faʻamamaina e vavae ese ai le paclitaxel mama mai le paluga tali.
E ui lava ala faanatura biosynthetic opaclitaxelua suʻesuʻeina, o le gaosiga moni o le paclitaxel o loʻo tumau pea le luʻitau ona e manaʻomia le tuʻufaʻatasiga lavelave ma le tele o laasaga ma le tele o mea mataʻutia. Ona o nei luʻitau, ua suʻesuʻeina foi e saienitisi auala faʻapipiʻi e faʻapipiʻi ai le paclitaxel ina ia faʻateleina lona fua ma avanoa. fa'asologa o le paclitaxel e masani lava ona aofia ai se auala fa'afaigofie e fa'aitiitia ai le lavelave.
Manatua: O faʻamanuiaga ma faʻaoga o loʻo tuʻuina atu i lenei tusiga e maua mai i tusitusiga lolomi.
Yunnan Hande Biotechnology Co., Ltd. ua taulaʻi i le gaosiga o le paclitaxel mo le 26 tausaga, ma o se kamupani tutoʻatasi o le paclitaxel vailaʻau faʻamaʻi faʻamaʻi faʻamaʻi mai laau ua faʻamaonia e le United States FDA, European EDQM, Ausetalia TGA, Saina CFDA , Initia, Iapani ma isi ofisa fa'atonutonu a le atunu'u. Yunnan Hande paclitaxel, tu'ufa'atasia, fale gaosi oloa fa'atau sa'o, fa'afeiloa'i e fesili, 18187887160(WhatsApp le numera tutusa)
Taimi meli: Oke-12-2023